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SESSION I: OPENING SESSION

Welcome and Opening Remarks

* Dr. Suzanne Harris, International Life Sciences Institute (ILSI)
* Mr. Robert Ferguson, NSF International
* Dr. Jamie Bartram, World Health Organization (WHO)

Keynote speaker – Dr. Jamie Bartram, World Health Organization (WHO)

Introduction: Rome Meeting Summary, Symposium Purpose and Focus on Calcium and Magnesium, and Charge to the Technical Sessions

* Dr. Joseph Cotruvo, Joseph Cotruvo & Associates, USA

SESSION II: DIETARY MINERALS CONSUMPTION AND HEALTH

Basis for worldwide Recommended Daily Allowances for calcium and magnesium

* Dr. Stephanie Atkinson, McMaster University, Canada and Dr. Rebecca Costello, National Institutes of Health, USA

Estimated average requirements for calcium and magnesium: data from human balance studies

* Dr. Mamoru Nishimuta, The Incorporated Administrative Agency of Health and Nutrition, Japan

Dietary intakes of calcium and magnesium: a comparison with dietary guidelines

* Dr. Joyce Donohue, US Environmental Protection Agency, USA

SESSION III: WATER AS A SOURCE OF DIETARY MINERALS IN WORLD REGIONS

Water mineral composition characteristics (tap water, bottled, mineral, spring, desalinated) in the world regions

* Dr. Choon Nam Ong, National University of Singapore, Singapore

Water/fluid consumption patterns among the general populations and subpopulations including high-risk segments

* Dr. Ann Grandjean, The Center for Human Nutrition, and Dr. Robert Heaney,

Creighton University, USA

Contribution of drinking water to calcium and magnesium intake in Europe

* Dr. Caroline van den Hooven and Dr. Jeanne de Vries, Wageningen University and Ms. Margreet Mons, KIWA Water Research, The Netherlands

Commenter: Dr. Jonathan C. Allen, North Carolina State University, USA

SESSION IV: BASIS FOR LINKING MAGNESIUM, CALCIUM AND HEALTH OUTCOMES

Cardiovascular aspects of magnesium deficiency

* Dr. William Weglicki, George Washington University Medical Center, USA

Magnesium and hypertension

*
Dr. Rhian Touyz, Ottawa Health Research Institute, Canada

Challenges and importance of the assessment of magnesium status

* Dr. Ronal Elin, University of Louisville, USA

Commenter: Dr. Earl Ford, Centers for Disease Control and Prevention, USA

Commenter: Dr. Burton Altura, SUNY Downstate Medical Center, USA

SESSION V: CONTROLLED HUMAN EXPOSURE STUDIES OF MAGNESIUM AND/OR CALCIUM IN DIET/DRINKING WATER

Indications of magnesium and calcium deficiency in populations

* Dr. Gerald Combs, USDA Grand Forks Human Nutrition Research Center, USA

Calcium studies and role of drinking water

* Dr. Constance Weaver, Purdue University, USA

Dietary magnesium deprivation confirmed by balance induces biochemical and functional changes including increased calcium balance in postmenopausal women

* Dr. Forrest Nielsen, USDA Grand Forks Human Nutrition Research Center, USA

Commenter: Dr. Nickolas G. Zimmermann, University of Maryland, USA

SESSION VI: BASIS FOR LINKING MAGNESIUM, CALCIUM AND HEALTH OUTCOMES II

Calcium and magnesium in drinking water in relation to bone metabolism

* Dr. Jeri Nieves, Helen Hayes Hospital and Columbia University, USA

Studies on the effects of taking of partially desalinated deep seawater on bone metabolism and blood pressure in postmenopausal women with osteopenia or osteoprosis

* Dr. Toshiyuki Sado and Dr. Hajime Morikawa,

Nara Medical University, Japan

Magnesium and the immune system

* Dr. Terez Shea-Donohue, University of Maryland, USA

Commenter: Dr. Mieko Kimura, Takeda Research Institute of Life Science and Preventive Medicine, Japan

SESSION VII: EPIDEMIOLOGICAL EVIDENCE LINKING DRINKING WATER COMPONENTS AND HEALTH – CARDIOVASCULAR AND OTHER DISEASES I

Overview of epidemiologic methods, strengths and weaknesses

* Dr. Rebecca Calderon, US Environmental Protection Agency, USA

Findings from UK systematic review on water hardness and cardiovascular mortality and other effects

* Dr. Paul Hunter, University of East Anglia, UK

Studies needed to improve the database and interpretations

* Dr. Martha Sinclair, Monash University, Australia

SESSION VIII: EPIDEMIOLOGICAL EVIDENCE LINKING DRINKING WATER COMPONENTS AND HEALTH – CARDIOVASCULAR AND OTHER DISEASES II

Health effects of long-term consumption of water low in calcium, magnesium or TDS: studies from Eastern Europe

* Dr. Frantisek Kozisek, National Institute of Public Health, Czech Republic

Calcium and magnesium in drinking water and risk of death from cardiovascular diseases: epidemiological evidence from Taiwan

* Dr. Chun-Yuh Yang, Kaohsiung Medical University, Taiwan

Water quality and health in British men: old and new evidence from the British Regional Heart Studies

* Dr. Richard Morris, University College London, UK

Commenter: Dr. Ragnar Rylander, Professor emeritus, Gothenburg University, Sweden

SESSION IX: ALTERNATIVE HYPOTHESES AND KNOWLEDGE GAPS

Alternative health effects interpretations

* Dr. Shailendra Vajpeyee, Government Medical College and New Civil Hospital, India

Are there health consequences from long term consumption of low or high TDS water?

* John Fawell, John Fawell Associates, UK

Israeli standards for calcium in desalinated water

* Dr. Avner Adin, Hebrew University of Jerusalem, Israel

Corrosion and soft vs. softened water

* Joseph Harrison, Water Quality Association, USA

SESSION X: WATER PRODUCTION, TECHNICAL ISSUES AND ECONOMICS

Drinking water hardness: reasons and criteria for softening and benefits of the optimal composition of drinking water

* Dr. Margreet Mons, KIWA Water Research, The Netherlands

Feasibility and costs of mineral supplementation of bottled water and beverages

* Josep Molas Pages, Coca-Cola Company Iberian Division, Spain

Twenty years of experience with central softening in The Netherlands: Water quality – Environmental benefits – Costs

* Dr. Jan Peter van der Hoek, Amsterdam Water Supply, The Netherlands

Options for nanofiltration and reverse osmosis permeate remineralization

* Dr. Maarten Nederlof, Vitens, The Netherlands

Business impacts of the ‘hard water benefits’ hypothesis

* Dr. Regu P. Regunathan, ReguNathan Associates, USA

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